November 9

Adaptogen Series – Reishi Mushrooms

by Dr. Dov Pine

Reishi mushrooms are the first feature of my adaptogen series. More to come on mushrooms and more to come on adaptogens. Enjoy!

Two weeks ago Alondra and I were enjoying a holiday up in the Daintree Rainforest in far north Queensland. We saw tons of reishi mushrooms growing along fallen trees along the trail sides all over the forest floor- they were beautiful.

We have enjoyed using Reishi mushrooms in evening teas for a number of years now and its about time I put together an article covering their significant health, adaptogenic, and anti-cancer implications. Knowing I will write more on Reishi mushrooms in the future, I would like to focus on their adaptogenic properties related to stress and anti-aging.

The Reishi mushroom (Ganoderma lucidum) is the most widely researched medicinal mushroom and rightfully so, considering the breadth of its health applications.

Known in Chinese as Lingzhi which means Herb of Spiritual Potency, the reishi mushroom is revered in Asian culture for its myriad of medicinal qualities.

Even the Chinese goddess Kuan Yin is sometimes represented holding this special mushroom. The reishi as a symbol often depicts success, divine power, health and longevity.

Reishi Mushrooms

Researched performed by Wachel-Galor et al. shows that reishi mushrooms have been formally documented in Chinese medicine as early as 502-536 AD in the Supplement to Classic of Materia Medica. Centuries later in the year 1590 AD during the Ming Dynasty, the first Chinese definitive pharmacopeia, Ben Cao Gang Mu by Li Shin-Zhen, attributes the therapeutic properties of tonification, building Qi and vital energy, strengthening heart function, memory and anti-aging to the reishi mushroom.

I recall reading once that reishi mushrooms grow on all continents on deciduous trees and are often found fruiting in abundance.

The medicinal properties of reishis are due to their unique polysaccharide, peptidoglycan and triterpine content including ganoderic and lucidenic acids. There are more than 120 bioactives and 50 different types of polysaccharides and peptidoglycan complexes found in reishi mushrooms.1

Interestingly, reishi mushrooms have pharmaceutical value, but little value as a food. The fruiting body, spores and mycelia are all commonly utilized in its preparations for teas, powders and extracts. As a side note, mushrooms contain all essential amino acids and have a particular abundance of lycine and leucine. So the next time the topic of plant based protein sources comes up…

Understanding Adaptogens

More than a buzz word, Adaptogens are agents that increase an organism’s non specific resistance to stress through its ability to adapt. This applies to the different stages of stress as defined by Hans Selye: alarm, resistance and exhaustion. Adaptogenic substances are often wide acting and as Panossian (2017) explains, their effects range from protection against chronic inflammation, atherosclerosis, neurodgenerative cognitive impairment, metabolic disorders, cancer, stress induced fatigue and other aging related diseases.2 Commonly known adaptogens other than reishi include ginseng, withania, schisandra, tulsi, eleutherococcus, rhodiola, cordyceps, and codonopsis.

Reishi mushrooms are among the true adaptogens that support adrenal function and act upon the HPA or hypothalamic-pituitary-axis.3  Adaptogens contain significant antioxidants, protect cell membrane and DNA integrity, energy production, brain function and hormone support. Basically, they reduce internal metabolic stress which in turn promotes greater cognitive function, cellular and DNA longevity, anti-aging, fertility and libido, immune function, energy and overall greater health. For this reason we can apply concepts like vitality, anti-aging and cognition in the same basket.

reishi mushrooms
Reishi fruiting bodies young and old in the Daintree rainforest.

Antioxidant and Anti-aging Activity

The bioactives in reishi have demonstrated DNA protective effects as well as free radical scavenging and chelating abilities. In fact, the reishi polysaccharides and peptidoglycans mimic our endogenous antioxidant superoxide dismutase (SOD) and are able to protect cellular DNA from a variety of harmful agents including UV exposure, hydrogen peroxide and even chemotherapy.4-7 Any factor that protects DNA from oxidation preserves cellular life, reduces telomere overuse, reduces cellular mutagenic potential and senescence. This is a technical way of saying the factors that characterize cellular youth remain intact longer. That is the basic principle of anti-aging. When the cells stay younger due to reduced damage so does the body and brain.

Anti-Depression and Anti-Anxiety Effects

Happiness and vitality are inextricably connected. Reduced happiness or depression is often observed in fact to outwardly accelerate the aging process. Reishi mushrooms are traditionally used for conditions including depression and anxiety, but few modern studies have been performed to substantiate the evidence other than a 20138 and 20169 study. The anti-depression and anti-anxiety effects attributed to reishi mushrooms may be due to the adrenal supporting properties and Qi building (vitality-life force) as discussed in Traditional Chinese Medicine.

Anti-Cancer and Anti-Metastasis

The beta glucans present in reishi mushrooms stimulate the human immune system to better recognize and tag cancer cells, while at the same time recruit B, T and Natural Killer cells to attack the cancer and reduce metastasis. These interactions have been observed with both in vivo and in vitro studies.22

The reishi mushroom anti-cancer effects have been observed specifically in breast cancer,10,11 ovarian cancer,17 lung12 and liver cancers,13,14 bladder cancer,15 colorectal cancer,18,19 leukemias, lymphomas and multiple myeloma.16,20,21 Beyond their anti-cancer properties, reishis have unique protective effects on patients undergoing chemo and radiotherapies.22 They enhance immune function, and protect against white and red blood cell depletion that occurs as “collateral damage” during chemotherapy.  Of course, years of research is required to further explore these findings and develop appropriate clinical tools.

reishi mushroom of the Daintree rainforest
A lonely reishi fruiting body.

Liver Protective

In addition to supporting the adrenal system, the adaptogenic properties of reishi mushrooms have protective effects on the liver. The liver is our internal apothecary, pharmacy and dispensary. It produces and breaks down an enormous amount of hormones and peptides responsible for countless functions in the body. When the liver goes down, all functions begin to fail.

In a number of studies on rats with induced liver damage, reishi extracts showed statistically significant reduction in “damage indicator enzyme levels” including AST, ALT, and alkaline phosphatase (ALP). The studies involved various forms of chemically induced damage,23-25 as well as hepatitis B.26 Another study demonstrated improved liver morphology and histological (tissue) composition in liver cirrhosis due to biliary obstruction.27

Putting It All Together

DNA protection, stress reduction, anti-aging, liver protection, anti-depression, immune strengthening and anti-cancer effects are among the health properties exhibited by reishi mushrooms- the Chinese Herb of Spiritual Potency for longevity. Not a bad list for why you should drink reishi tea at home.  

Using Reishi At Home

At home we generally prepare Reishi tea by itself, not in mixtures with other things. Reishi is easy to include in your morning coffee if you are coffee person. I like to use a 30-40% plus polysaccharide level extract, 1/2 teaspoon per mug for making a tea.

If using a whole reishi mushroom fruiting body, you can break off a piece, boil it for up to 20 minutes and then drink the tea. Continue to use the same piece of mushroom until it stops giving color when re-boiled. Enjoy!

Disclaimer. The information represented in this article is meant to provide concepts from evidence based research. It is not intended to treat or diagnose any health condition. For appropriate treatment methods please contact your healthcare provider. 

  1. El Enshasy HA,  Hatti-Kaul R. Mushroom immunomodulators: unique molecules with unlimited applications. Trends Biotechnol.2013 Dec;31(12):668-77.
  2. Panossian A. Understanding adaptogenic activity: specificity of the pharmacological action of adaptogens and other phytochemicals. Ann N Y Acad Sci. 2017 Aug;1401(1):49-64
  3. Lian-ying L et al. A preliminary review of studies on adaptogens: comparison of their bioactivity in TCM with that of ginseng-like herbs used worldwide. Chin Med. 2018; 13: 57. Published online 2018 Nov 16. doi: 10.1186/s13020-018-0214-9
  4. Ooi VE, Liu F. Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Curr Med Chem. 2000 Jul;7(7):715-29.
  5. Lee JM et al. Inhibition of lipid peroxidation and oxidative DNA damage by Ganoderma lucidum. Phytother Res. 2001 May;15(3):245-9.
  6. 6. Shi YL et al. Mushroom-derived preparations in the prevention of H2O2-induced oxidative damage to cellular DNA. Teratog Carcinog Mutagen. 2002;22(2):103-11.
  7. Mau JL et al. Antioxidant properties of several medicinal mushrooms. J Agric Food Chem. 2002 Oct 9;50(21):6072-7.
  8. Matsuzaki H et al. Antidepressant-like effects of a water-soluble extract from the culture medium of Ganoderma lucidum mycelia in rats. BMC Complement Altern Med. 2013 Dec 26;13:370.
  9. Singh R, et al. Evaluation of Antianxiety Potential of Four Ganoderma (Agaricomycetes) Species from India in Mice. Int J Med Mushrooms.2016;18(11):991-998.
  10. Suarez-Arroyo IJ et al. Anti-tumor effects of Ganoderma lucidum (reishi) in inflammatory breast cancer in in vivo and in vitro models. PLoS One. 2013;8(2):e57431.
  11. Jiang J et al.Ganoderma lucidum suppresses growth of breast cancer cells through the inhibition of Akt/NF-kappaB signaling. Nutr Cancer.2004;49(2):209-16.
  12. Kashimoto N et al.Inhibitory effect of a water-soluble extract from the culture medium of Ganoderma lucidum (Rei-shi) mycelia on the development of pulmonary adenocarcinoma induced by N-nitrosobis (2-hydroxypropyl) amine in Wistar rats. Oncol Rep.2006 Dec;16(6):1181-7.
  13. Weng CJ et al.Inhibitory effects of ganoderma lucidum on tumorigenesis and metastasis of human hepatoma cells in cells and animal models. J Agric Food Chem.2009 Jun 10;57(11):5049-57.
  14. Aimei Li et al.Ganoderma lucidum polysaccharide extract inhibits hepatocellular carcinoma growth by downregulating regulatory T cells accumulation and function by inducing microRNA-125b. J Transl Med. 2015; 13: 100.
  15. Lu QY et al.Ganoderma lucidum extracts inhibit growth and induce actin polymerization in bladder cancer cells in vitro. Cancer Lett.2004 Dec 8;216(1):9-20.
  16. Müller CI et al.Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells. Leuk2006 Jul;30(7):841-8.
  17. Hsieh TC,Wu JM.Suppression of proliferation and oxidative stress by extracts of Ganoderma lucidum in the ovarian cancer cell line OVCAR-3. Int J Mol Med. 2011 Dec;28(6):1065-9.
  18. Liu J et al.Anti-androgen effects of extracts and compounds from Ganoderma lucidum. Chem Biodivers.2009 Feb;6(2):231-43.
  19. Dan X et al.A Ribonuclease Isolated from Wild Ganoderma Lucidum Suppressed Autophagy and Triggered Apoptosis in Colorectal Cancer Cells. Front Pharmacol.2016 Jul 25;7:217.
  20. Chang YH et al.Ganoderma lucidum extracts inhibited leukemia WEHI-3 cells in BALB/c mice and promoted an immune response in vivo. Biosci Biotechnol Biochem.2009 Dec;73(12):2589-94.
  21. Calviño E et al.Ganoderma lucidum induced apoptosis in NB4 human leukemia cells: involvement of Akt and Erk. J Ethnopharmacol.2010 Mar 2;128(1):71-8
  22. Guggenheim AG et al.Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology. Integr Med (Encinitas). 2014 Feb;13(1):32-44.
  23. Lin J. M, Lin C. C, Chen M. F, Ujiie T, Takada A. Radical scavenger and antihepatotoxic activity of Ganoderma formosanum, Ganodermalucidum and Ganoderma neo-japonicum. J Ethnopharmacol. 1995;47:33–41.
  24. Shi Y, Sun J, He H, Guo H, Zhang S. Hepatoprotective effects of Ganoderma lucidum peptides against D-galactosamine-induced liver injury in mice. J Ethnopharmacol. 2008;117:415–19.
  25. Lakshmi B, Ajith T. A, Jose N, Janardhanan K. K. Antimutagenic activity of methanolic extract of Ganoderma lucidum and its effect on hepatic damage caused by benzo[a]pyrene. J Ethnopharmacol. 2006;107(2):297–303.
  26. Li Y. Q, Wang S. F. Anti-hepatitis B activities of ganoderic acid from Ganoderma lucidum. Biotechnol Lett. 2006;28(11):837–41.
  27. Park E. J, Ko G, Kim J, Dong H. S. Antifibrotic effects of a polysaccharide extracted from Ganoderma lucidum, Glycyrrhizin, and Pentoxifylline in rats with cirrhosis induced by biliary obstruction. Biol Pharm Bull. 1997;20:417–20. 

About the author

Dr. Dov Pine

Dov is a Chiropractor and Applied Kinesiologist with a clinical focus in health restoration and individual potential through Meaning and Responsible Action. Dr. Pine lives in Newcastle, New South Wales and attends patients at Chiropractic Plus in New Lambton and Warners Bay.

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Medicinal Mushrooms – Topic

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